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replication, transcription, alkylate one base causing joining of two bases. dna cross-linking, breaks interfere rna, protein synthesis pharmacokinetics given oral / iv, metabolized by microsomal enzymes, mainly conjugated and excreted out. resistance different mechanisms: . decreased permeation into cells
. increased dna repair by cells . increased production of glutathione (gl- s transferase) leading to glutathione conjugation, making alkylating agent ineffective. toxicity same as in general toxicity with some additional effects uses blood, bone marrow lymphomas, breast, ovarian, gastero-esophageal,...
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