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well characterised, the biological meanings of many other "signs", particularly those newly identified histone marks, remain mysterious. in a search for new chromatin "road sign", dr li's team discovered a novel histone mark, lysine glutarylation (kglu) at histone h , lysine- (h k glu) from human cells
"and this 'sign' seems to be conserved in evolution, as we found it in not only human but also mouse, fly, worm and even baker's yeast cells." besides marking the active genomic region, h k glu in fact directly contributes to the formation of the more open accessible chromatin structure facilitating...
https://chemistry.hku.hk/research/department_news_detail/27/