nitrovasodilators . it releases no, which acts as a gaseous signaling molecule , relaxing the smooth muscles of blood vessels . [ ] [ ] pharmacokinetics[ edit ] the substance is quickly and almost completely (> %) absorbed from the gut. molsidomine is a prodrug that is hydrolysed to linsidomine (sin- ) in the liver...
protein, and other drugs that bind to plasma proteins. higher drug concentrations would lead to a higher fraction unbound, because the plasma protein would be saturated with drug and any excess drug would be unbound. if the amount of plasma protein is decreased (such as in catabolism , malnutrition , liver...
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into bile. excretion by kidneys into urine. water soluble hormones(peptides and catecholamines) are degraded by enzymes in the blood or tissues and are excreted by kidneys or liver. they have a short half life. lipid soluble hormones(steroids) are protein bound and are cleared slowly. - - editor share...
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