are membrane-associated and diffuse from the plasma membrane into the intermembrane space where they can reach and regulate membrane-associated effector proteins hydrophilic molecules: water-soluble molecules, such as camp , cgmp , ip , and ca + , that are located within the cytosol gases : nitric oxide...
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nonparenchymal cells (npcs). these cells, particularly kupffer cells, play an important role in the modulation of xenobiotic metabolism in the liver. kupffer cells secrete potent mediators of the inflammatory response that controls liver inflammation. these cytokine mediators control hepatocyte metabolic...
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contributes to the development of type 2 diabetes, atherosclerosis, liver disease and some forms of cancer. diet induced obesity in mice impairs t cell response and causes greater severity of disease and death after infection with influenza. obesity is associated with aberrant population expansion of cells...
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) comprise about percent of liver tissue; they participate in numerous metabolic and secretory functions. a second class of cells, called kupffer cells, line the vascular networks; their primary role is to recycle red blood cells that are no longer functional. the liver is also shot through with bile...
neuroendocrine tumors can form anywhere neuroendocrine cells are in the body. most commonly, they are in the digestive tract (stomach, appendix, small intestine, colon or rectum) or the lungs. neuroendocrine tumors can also develop in the pancreas (pancreatic neuroendocrine tumors or pnets). a separate...