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to calcium, synaptotagmins were proposed to function as calcium sensors in the regulation of neurotransmitter release and hormone secretion. although synaptotagmins share a similar domain structure and a high degree of homology in the c domains, not all synaptotagmins bind to calcium. in fact, only
eight out of the fifteen synaptotagmins are capable of calcium binding. the calcium binding synaptotagmins include synaptotagmins , , , , , , , and . the remaining seven synaptotagmins do not bind to calcium due to the lack of calcium coordinating residues or spatial orientation of the acidic residues...
https://en.wikipedia.org/wiki/Synaptotagmin