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opioids.[ ] a dose of approximately mg (oral) of codeine must be administered to give analgesia approximately equivalent to mg (oral) of morphine (rossi, ). however, codeine in general isn't used in single doses greater than mg (and no more than mg in hours).[ ][ ] when analgesia beyond mg of codeine
, % of asians, and % of arabs[ ] are "poor metabolizers"; they have little cyp d , and codeine is less effective for analgesia in these patients (rossi, ). srinivasan, wielbo and tebbett speculate that codeine- -glucuronide is responsible for a large percentage of the analgesia of codeine, and, thus,...
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