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the bone marrow become abnormal lymphocytes and these abnormal cells have difficulty fighting infections. as the number of abnormal cells grows there is less room for healthy white blood cells, red blood cells, and platelets. this could result in anaemia, infection, and bleeding. b-cell receptor signalling
of response, as well as overall survival, patient-reported outcomes and time to next treatment. , calquence calquence (acalabrutinib) is a next-generation, selective inhibitor of bruton's tyrosine kinase (btk). calquence binds covalently to btk, thereby inhibiting its activity. , in b-cells, btk signalling...
https://www.astrazeneca.com/media-centre/press-releases/2020/calquence-recommended-for-approval-in-the-eu-by-chmp-for-chronic-lymphocytic-leukaemia.html