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quickgo search pmc articles pubmed articles ncbi proteins guanylate cyclase ( ec . . , also known as guanyl cyclase, guanylyl cyclase, or gc) is a lyase enzyme . guanylate cyclase is often part of the g protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high

, and can also function as an autocrine signal . depending on cell type, it can drive adaptive/developmental changes requiring protein synthesis . in smooth muscle , cgmp is the signal for relaxation, and is coupled to many homeostatic mechanisms including regulation of vasodilation , vocal tone, insulin...

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