Primary cell

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solved. [ ] [ ] calcium ions induce conformational changes in the gla domain and are necessary for the gla domain to fold properly. a common structural feature of functional gla domains is the clustering of n-terminal hydrophobic residues into a hydrophobic patch that mediates interaction with the cell

surface membrane. [ ] at present, the following human gla-containing proteins (gla proteins) have been characterized to the level of primary structure: the blood coagulation factors ii (prothrombin), vii, ix, and x, the anticoagulant proteins c and s, and the factor x-targeting protein z . the bone...

https://en.wikipedia.org/wiki/Gla_domain

metastatic urothelial carcinoma who have disease progression during or following platinum-containin chemotherapy or have disease progression within months of neoadjuvant or adjuvant treatment with a platinum- containing chemotherapy. indications and usage[ , ] •unresctable or metastatic cancer •renal cell

carcinoma •urothelial carcinoma •squamous cell carcinoma of the head and neck •classical hodgkin lymphoma •lung cancer dosage and administration administer mg/kg as an intravenous infusion over minutes every weeks. warning and precautions •immune-mediated pneumonitis: stop the therapy for moderate and...

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more than risk loci in ms (see the perspective by briggs). focusing on the best candidate genes, including a model of the major histocompatibility complex region, the authors identified statistically independent effects at the genome level. gene expression studies detected that every major immune cell

decade, certain elements of the genetic architecture of susceptibility have gradually emerged, but most of the genetic risk for ms remained unknown. rationale earlier versions of the ms genetic map had highlighted the role of the adaptive arm of the immune system, implicating multiple different t cell...

https://science.sciencemag.org/content/365/6460/eaav7188