gprk-phosphorylated receptor and sterically preclude its coupling to the cognate g-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. the beta-arrestins target many receptors for internalization by acting as endocytic adapters (clasps...
gprk-phosphorylated receptor and sterically preclude its coupling to the cognate g-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. the beta-arrestins target many receptors for internalization by acting as endocytic adapters (clasps...
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