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used in cancer chemotherapy methotrexate, -fluorouracil, purine antagonists and antibiotics used in cancer chemotherapy pharmacology views anti-metabolites anti metabolites are used to inhibit different metabolic pathways, as rate of metabolism and required metabolites are much higher for malignant cells
methotrexate mechanism of action inhibits dihydrofolate reductase – blocks conversion to tetrahydrofolate for synthesis of many cellular components. interferes with synthesis of thymidylate, purine, serine, methionine, proteins, rna, dna pharmacokinetics given orally, i/v or by intrathecal route in cells...
http://howmed.net/pharmacology/methotrexate-5-fluorouracil-purine-antagonists-and-antibiotics-used-in-cancer-chemotherapy/