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well known, and the term "laudanum" came to refer to any combination of opium and alcohol. several physicians, including john jones, john brown, and george young, the latter of whom published a comprehensive medical text entitled treatise on opium, extolled the virtues of laudanum and recommended the
"diarrhoea (chronic)": aqueous extract of ergot, grains; extract of nux vomica, grains; extract of opium, grains, "make pills. take one pill every three or four hours." [ ] the early th century brought increased regulation of all manner of narcotics, including laudanum, as the addictive properties of...
https://en.wikipedia.org/wiki/Laudanum